P-125: The Pregnancy Success Rate of IVF/ICSI with and without The Use of PGSin Female Partner over 35 Years Old Referred to Tehran Infertility Centers

Background: Preimplantation genetic aneuploidy screening (PGS) has been performed during the last decade as a way of enhancing embryo selection in patients with an increased incidence of embryonic numerical chromosome abnormalities (advanced maternal age, recurrent miscarriage, and recurrent implantation failure). It has been proposed that the replacement of euploid embryos in these patients would result in a higher implantation and pregnancy rate and a reduced miscarriage rate. Additionally, the transfer of fewer embryos could reduce the chances for multiple pregnancies in all IVF patients. Advanced maternal age (AMA) is an important parameter that negatively influences the clinical pregnancy rate in IVF, in particular owing to the increased embryo aneuploidy rate.Although, to date, multiple studies have addressed this issue, contradictory results have been encountered. The purpose of this study was to test whether or not employing preimplantation genetic screening (PGS) in AMA patients would increase the clinical pregnancy rate. Materials and Methods: In our study, couples with female partner over 35 years of age were participated in a randomized controlled trial (RCT). Results of embryo transfer following PGS using FISH technique for chromosomes 13, 18, 21, X/Y were evaluated and compared with those in control group. Results: 150 couples with female partner over 35 years old were included in this study. Of these, 50 couples underwent PGS and the remaining were used as control group. Pregnancy rates obtained in PGS and control group were 30 and 32%, respectively. Conclusion: These two groups showed no significant difference in comparison with each other and therefore in conclusion PGS for chromosomes 13, 18, 21, X and Y does not elevate IVF/ICSI success rate in women over 35 years of age.